Peptides for Menopause & Hormonal Support
Traditional hormone therapy (HRT) is powerful, but it’s only one part of the puzzle. Most perimenopausal and menopausal women are experiencing systemic changes that affect energy, mood, libido, body composition, skin health, and recovery.
Peptides allow you to support this population holistically, either alongside BHRT or as a standalone alternative. By addressing mitochondrial function, growth hormone production, sexual signaling, and mood stability, you can offer a more complete and tailored plan for the modern midlife woman.
The Menopause Patient Profile
Use this stack when a patient reports:
- Fatigue or “hitting a wall” mid-afternoon
- Increased abdominal fat despite diet/exercise
- Mood swings, anxiety, or low motivation
- Hot flashes, poor sleep, or night sweats
- Loss of libido, vaginal dryness, or pain with sex
- Poor skin elasticity, dryness, or hair thinning
This is ideal for women in:
- Perimenopause (mid-late 30s to early 50s)
- Postmenopause (12+ months since last period)
- Surgical menopause or hormonal suppression cases
ShineRx Menopause Stack Compounds
These are the top ShineRx compounds used to support menopausal women:
| Compound | Function | Notes |
| Sermorelin | Growth hormone support for recovery, sleep, body comp | Enhances mood, energy, and metabolic resilience |
| Gonadorelin | LH/FSH stimulation, libido support, ovarian axis support | Safe alternative to testosterone or DHEA in some cases |
| Glutathione | Detox, skin clarity, oxidative stress control | Improves cellular recovery, antioxidant defense |
| NAD+ | Mitochondrial support, mood, brain fog reduction | Especially effective in foggy, exhausted patients |
| MIC/B6/B12 | Fat metabolism, methylation, mood enhancement | Supports body comp, emotional resilience, and detox pathways |
| PeptideVite | Micronutrient support to optimize peptide response | Encourages better peptide absorption and tissue response |
Optional supportive additions:
- Estradiol / Progesterone (via prescription if BHRT is in place)
- Tirzepatide or Semaglutide (if weight gain or insulin resistance is present)
- L-Carnitine (to enhance fat oxidation and stamina)
Sample Protocol Template (SQ or IM Plan)
| Day | Compound | Dosage | Notes |
| M/W/F | Sermorelin | 300mcg SQ | Administer at night to promote restful sleep and GH |
| Tu/Th | Gonadorelin | 100mcg SQ | Supports libido, mood, and hormonal signaling |
| Weekly | MIC/B6/B12 | 1mL IM | Energy, methylation, and fat metabolism support |
| Weekly | Glutathione | 200mg IM/SQ | Detox and skin clarity support |
| Weekly | NAD+ | 50–100mg SQ | Can be titrated depending on tolerance and fatigue |
| Daily Oral | PeptideVite | As directed | Enhances results across all peptide protocols |
Clinical Expectations
Patients will typically report:
- Fewer hot flashes and better thermal regulation
- Increased libido and mood stability by week 3–4
- Fatigue reduction, improved motivation
- Smoother skin, improved tone, and reduced dryness
- Better sleep and easier recovery from workouts or stress
Note: For BHRT patients, these peptides complement hormone optimization without over-saturating one pathway. For HRT-free patients, peptides can offer a non-hormonal support path.
How to Introduce This Stack to Patients
- Explain how aging impacts not just hormones, but mitochondrial health, recovery, and cellular signaling
- Position peptides as restorative, not replacement compounds
- Clarify that they work gradually (2–6 weeks) and are best used consistently
- Highlight benefits beyond menopause: skin, sleep, libido, energy, metabolism
Implementation Notes
- Use this stack to build menopause-focused memberships or programs
- Offer as an HRT alternative for women not ready or eligible for hormones
- Create easy patient-facing guides using ShineRX’s white-labeled handouts
- Combine with weight loss or aesthetic services to increase monthly revenue